Abstract

Herpes Simplex Virus Epigenetic modifications are a sort of genetic metadata—they alter gene expression without changing the underlying DNA. Hill et al. hypothesized that epigenetic modification could be exploited for treating herpes virus infection. Herpes virus infection and reactivation from latency depends on the histone demethylases LSD1 and JMJD2, which are responsible for making epigenetic marks on chromosomes. Epigenetic modifications inhibited viral infection in animal models that represent three different stages of herpes simplex virus infection: suppression of primary infection, a block to subclinical shedding, and reduction in recurrent lesions. Sci. Transl. Med. 6 , 265ra169 (2014).

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