Abstract
IL-10 is a regulator of inflammation and immunosuppression. IL-10 regulates a variety of immune cells to limit and stop the inflammatory response, and thus plays an important role in autoimmune diseases, inflammatory diseases and cancer. IL-10 is closely related to epigenetic modification, in which changes in DNA methylation of IL-10 gene can affect mRNA and protein levels of IL-10. In addition, changes in histone modifications, especially histone acetylation, can also lead to abnormal expression of IL-10 mRNA. At the same time, a handful of IL-10 related microRNAs (miRNAs) are found to be aberrantly expressed in multiple diseases. Besides, long non-coding RNA (lncRNA) growth arrest specific transcript 5 (GAS5) also inhibits IL-10 expression. Here, we reviewed the epigenetic changes related to IL-10 in various diseases, as well as the regulation of IL-10 gene expression in various diseases by epigenetic modifications such as DNA methylation, histone modification, miRNA, and lncRNA.
Highlights
As the primary member of the IL-10 cytokine family [1], IL-10 plays an important role in the regulation of the differentiation and proliferation of a variety of immune cells, such as T cells, B cells, natural killer cells, antigen presenting cells, mast cells, and granulocytes [2]
IL-10 is a highly potent cytokine produced by a variety of cells
It regulates cell growth and differentiation, participates in inflammatory reactions, and immune responses, and is currently recognized as inflammation and immunosuppressive factor. It plays an important role in autoimmune diseases and inflammatory diseases
Summary
As the primary member of the IL-10 cytokine family [1], IL-10 plays an important role in the regulation of the differentiation and proliferation of a variety of immune cells, such as T cells, B cells, natural killer cells, antigen presenting cells, mast cells, and granulocytes [2]. IL-10 is a highly potent cytokine produced by a variety of cells.
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