Abstract
Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.
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