Abstract
The Barker hypothesis holds that alterations to homeostasis during critical periods of development predispose individuals to adult-onset chronic diseases1. Previously, we found that mice conceived by IVF display altered growth and altered glucose homeostasis2. Further, it appears that epigenetic alterations might be the molecular mechanism responsible for the observed phenotypic alterations. To explore this possibility, we have assessed epigenetic alterations at selected loci in embryos and adult tissue of IVF and naturally conceived offspring.
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