Abstract
Bisphenol A (BPA) is extensively used in plastic products and epoxy resins. The epigenetic response to the environmental chemical BPA was involved in multiple dysfunctional categories, such as cancer, the reproductive system, metabolism, pubertal development, peripheral arterial disease, infant and childhood growth, and neurodevelopment outcomes. In this mini-review, we described the recent progress of the epigenetic effects of the environmental chemical BPA, including DNA methylation, histone methylation, and toxic epigenomics. Notably, the histone modification changes under BPA exposure are summarized in this review. DNA methylation accompanied by transcriptional changes in key genes affected by BPA exposure is related to various processes, including neural development, cancer pathways, and generational transmission. In addition, BPA could also affect histone modifications in many species, such as humans, rats, and zebrafish. Finally, we reviewed recent studies of the toxico-epigenomics approach to reveal the epigenetic effect of BPA exposure genome-wide.
Highlights
Bisphenol A (BPA) is one of the most extensively used chemical components in the plastics and epoxy resins of large consumer products, including water bottles, baby bottles and storage containers, pitchers, tableware, and other storage goods (Kamrin, 2004)
We summarized the recent discoveries of BPA-mediated epigenetic alterations in DNA methylation and histone modification
Kundakovic et al (2013) found that in utero BPA exposure induced sex-specific DNA methylation changes in ERα [estrogen receptor 1 (Esr1)] in the brain. They detected enduring DNA methylation changes in brain-derived neurotrophic factor (BDNF), a specific gene related to nervous system development, that were induced by parental BPA exposure (Kundakovic et al, 2015)
Summary
Bisphenol A (BPA) is one of the most extensively used chemical components in the plastics and epoxy resins of large consumer products, including water bottles, baby bottles and storage containers, pitchers, tableware, and other storage goods (Kamrin, 2004). NcRNAs have been found to be involved in various processes, such as histone modification, DNA methylation targeting, and gene silencing. We summarized the recent discoveries of BPA-mediated epigenetic alterations in DNA methylation and histone modification.
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