Abstract
Aim: To investigate associations of psychosocial stressors and resilience factors with DNA methylation age in thesaliva of Latinx children of immigrants before and after the 2016 presidential election (2015-2018). Materials & methods: We compared psychosocial exposures with four distinct measures of epigenetic age assessed in thesaliva of children (6-13years, n=71 pre-election; n=35 post-election). Exploratory genome-wide analyses were also conducted. Results: We found distinct associations acrossepigenetic clocks and time points;for example, greater maternal social status pre-election and fear of parent deportation post-election both associated with decreased Hannum age(p ≤ 0.01). Conclusion:Although limited in size, our unique study design provides novel hypotheses regarding how thesocial environment may influence epigenetic aging and genome-wide methylation, potentially contributing to racial/ethnic health inequalities.
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