Abstract
Background: Epidural anaesthesia is a safe alternative for general anaesthesia in patients undergoing infraumbilical surgeries. This study was conducted to evaluate the effect of clonidine as an adjuvant to levobupivacaine, an S (-) enantiomer of bupivacaine. Material and Methods: Hundred patients of ASA grade I and II undergoing infraumbilical surgeries were randomized in two groups as L and LC. Group L received 0.5% levobupivacaine (1.5mg/kg) and group LC received 0.5% levobupivacaine (1.5mg/kg) with clonidine (2µg/kg). The onset time for sensory, motor blockade, duration of anaesthesia and duration of analgesia, VAS score were observed in both the groups. The haemodynamic variables such as heart rate, systolic and diastolic blood pressure, respiratory rate and SPO 2 at various time intervals were measured. Any untoward side effects were noted in both groups. Results: The onset of sensory (7.8±1.7mins) and motor blockade (10.9±1.9mins) was significantly faster in clonidine group. Duration of anaesthesia and duration of analgesia was prolonged in group LC (234.5±16.1mins, 412.8±48.3mins) compared to group L (173.56±12.78 min, 269.2±24.2mins) which was statistically significant (p Conclusion: Clonidine as an adjuvant to levobupivacaine prolongs the post-operative analgesia and the duration of anaesthesia for infraumbilical surgeries.
Highlights
Pain management during surgery and postoperative period is an uphill task for an anesthesiologist and many breakthroughs have happened to alleviate pain
Duration of anaesthesia and duration of analgesia was prolonged in group LC (234.5±16.1mins, 412.8±48.3mins) compared to group L (173.56±12.78 min, 269.2±24.2mins) which was statistically significant (p
Levobupivacaine, a long acting local anesthetic and an S (-) enantiomer of bupivacaine has recently emerged as a safer alternative for regional anaesthesia than its racemic parent bupivacaine
Summary
Pain management during surgery and postoperative period is an uphill task for an anesthesiologist and many breakthroughs have happened to alleviate pain. Levobupivacaine, a long acting local anesthetic and an S (-) enantiomer of bupivacaine has recently emerged as a safer alternative for regional anaesthesia than its racemic parent bupivacaine. Levobupivacaine is preferred because of its less cardiotoxic effects.[1] the susceptibility for seizure activity with levobupivacaine is 1.5-2.5 times less than that of racemic bupivacaine.[2] Alpha -2- agonist exerts their analgesic activity in the spinal cord by activating the postganglionic alpha 2 receptors in the substantia gelatinosa of the spinal cord. This study was undertaken to evaluate the effects of clonidine as an adjuvant to levobupivacaine in epidural anaesthesia. Randomization of patients was done by sealed envelope technique. Patients were randomized into two equal groups as Group L and Group LC. Epidural anaesthesia is a safe alternative for general anaesthesia in patients undergoing infraumbilical surgeries. This study was conducted to evaluate the effect of clonidine as an adjuvant to levobupivacaine, an S (-) enantiomer of bupivacaine
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