Abstract
Epidermal stem cells undergo age-associated changes
Highlights
The causes underlying aging remain poorly understood
One prominent theory is that a decrease in stem cell function over time plays a significant role in tissue aging, which manifests at the organismal level
Using the well-characterized Keratin-15-GFP reporter mouse [3] to study and isolate stem cells during aging, this study identified increases in stem cell number but decreases in functional capacity of this population over time, and advances the hypothesis that broader age-associated stem cell alterations contribute significantly to skin aging
Summary
One prominent theory is that a decrease in stem cell function over time plays a significant role in tissue aging, which manifests at the organismal level. The noticeable exception to this idea was the fact that the skin, which contains some of the most amenable and best-studied stem cell populations and which progressively loses its ability to maintain tissue homeostasis with age, had no previously documented age-associated changes in stem cell function [1].
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