Abstract
The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptors have all recurred within two years of resection. Twenty-one percent of the lobular carcinomas contained EGF receptors compared to 34% of ductal carcinomas. EGF receptor status appeared to be associated with an increased risk of early recurrence and death whatever the histological sub-type of the breast cancer.
Highlights
Many prognostic variables have been described for use in the study of breast cancer
We present a series of 264 consecutive surgically resected breast cancer specimens with an analysis of histological type and Epidermal growth factor receptors (EGFr) and ER status
Twenty-five (9%) non-ductal carcinomas were identified in this series of 264 breast cancers
Summary
Tumours were collected fresh from theatre and processed immediately. Sections were taken for histological study and immuno-histochemistry and the remainder of the tissue used to assay ER and EGFr by radioligand binding methods. ER levels were determined by a dextran coated charcoal technique (Maynard & Griffiths, 1979) and EGFr by radioligand binding (Sainsbury et al, 1985a; Nicholson et al, 1988). The cut off point used to determine EGFr positivity was lOfmolmg-1 membrane protein (Nicholson et al, 1988) and lOfmolmg-1 cytosolic protein for ER positivity. The x2 test was used to analyse the results with Yate's modification if numbers were < 10 per cell or 100 in total
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