Abstract
We read with great interest the article by Kim et al. (1) about the role of the epidermal growth factor receptor (EGFR) in the tumor response after neoadjuvant treatment of locally advanced rectal cancer. We have some comments and reservations concerning certain aspects of the article. First, only 30 patients (16%) underwent endorectal ultrasonography. The pretreatment clinical TNM stage was thus determined mainly by computed tomography (CT). Endoluminal ultrasonography is now recognized as the most accurate modality compared with CT and magnetic resonance imaging (MRI) for the evaluation of local invasion of rectal cancer (2) and should be considered the standard medical examination for parietal infiltration evaluation before treatment.
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