Abstract
The process of cell division, growth, differentiation and death is a highly regulated process. Several class of trans membrane receptors play a pivot role in this process, of these, epidermal growth factor receptor (EGFR) a member of Receptor Tyrosine Kinase (RTK) family are best known. These comprises of four receptors Erb B1/HER 1, Erb B2 / HER 2, Erb B3/ HER 3, and Erb B4 / HER 4. Of these HER 2 is the most favoured target.
Highlights
The process of cell division, growth, differentiation and death is a highly regulated process
Several class of trans membrane receptors play a pivot role in this process, of these, epidermal growth factor receptor (EGFR) a member of Receptor Tyrosine Kinase (RTK) family are best known
To target aberrant signalling through EGFR, monoclonal antibodies were the first approach to be investigated
Summary
The process of cell division, growth, differentiation and death is a highly regulated process. Address: Assistant Professor, Department of Surgical Oncology, Regional Cancer Centre, Medical College P.O., Thiruvananthapuram, Kerala 695 011, India Email: Manoj Pandey* - manojpandey@vsnl.com; K Chandramohan - cm@vsnl.com * Corresponding author Published: 01 July 2003 World Journal of Surgical Oncology 2003, 1:9
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