Abstract
Epidemiology of hepatocellular carcinoma in nonalcoholic fatty liver disease
Highlights
Hepatocellular carcinoma (HCC) is the seventh most common type of cancer worldwide and the second most common cause of cancer-related death[1]
This paper aims to provide a review of the literature regarding the epidemiology of nonalcoholic fatty liver disease (NAFLD)-related HCC and elucidate the problems and challenges in cases of NAFLD-related HCC that have been on the rise
There has been a dramatic increase in the number of NAFLD patients, which is closely related to obesity, Type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS), as our food and lifestyle habits change
Summary
Hepatocellular carcinoma (HCC) is the seventh most common type of cancer worldwide and the second most common cause of cancer-related death[1]. 12.5-24.5 25 27.3 11.4 hepatitis B virus (HBV) and hepatitis C virus (HCV)[2,3], there has been a rapid increase in the number of cases of HCC from nonviral causes[4,5]. The prevalence of NAFLD is closely related to the increase in the prevalence of obesity[7,8], Type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, and metabolic syndrome (MetS)[9,10,11] and is increasing in both developed and developing nations, with approximately 30% of the world’s population being affected[12]. Higher incidence rate in older and male patients (compared with HCV-derived HCC). Detected more often in the advanced stage and with symptoms outside of surveillance (compared with HCV-related HCC). Less frequently elevated AFP levels (compared with HCV-related HCC) and often elevated PIVKA-II levels
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