Abstract
BackgroundAlthough many species of mycoplasmas regard as normal flora, but some species causes serious genital disease. In Iran several epidemiological studies have documented the prevalence of Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in genital disorders. This meta-analysis is going to represent the prevalence of M. hominis, M. genitalium and U. urealyticum among Iranian couples and the correlation between mycoplasmas infection and infertility.MethodsWe search online databases from January 2000 to June 2019. We used following MeSH keywords (Prevalence, M. hominis, M. genitalium, U. urealyticum, male, female, fertility, Infertility, genitourinary tract infection and Iran) with all possible combinations with “OR” and “AND”. Finally, forty-four articles from 2670 were chosen for data extraction and analysis by software using STATA version 14.0.ResultsThis meta-analysis revealed that the prevalence of U. urealyticum was 17.53% in Iran and the prevalence of M. genitalium and M. hominis were 11.33 and 9.68% respectively. The rate of M. genitalium, M. hominis and U. urealyticum infection in women with symptoms of genitourinary tract infection was higher than men with genitourinary tract infection (6.46% vs 5.4, 7.67% vs 5.88 and 21.04% vs 12.13%, respectively). As expected, the prevalence of M. genitalium, U. urealyticum and M. hominis among infertile women (12.73, 19.58 and 10.81%) were higher than fertile women (3%, 10. 85% and 4. 35%). Similarly, the prevalence of M. hominis and U. urealyticum among infertile men (14 and 21.18%) were higher than fertile men (4 and 3%). Based on this analysis, the rate of U. urealyticum was higher than M. genitalium and M. hominis among infertile men and women compared to the fertile group. The prevalence rate of M. genitalium, M. hominis and U. urealyticum in central provinces is higher than other parts of Iran.ConclusionsThis meta-analysis reemphasizes a significant relationship between the infertility rate and U. urealyticum, M. genitalium and M. hominis infections. Our finding help to plan the prevalence map of M. hominis, M. genitalium and U. urealyticum in Iran but further studies are needed to suggest routine screening of the pathogens.
Highlights
Many species of mycoplasmas regard as normal flora, but some species causes serious genital disease
Moridi et al BMC Public Health (2020) 20:1020 (Continued from previous page). This meta-analysis reemphasizes a significant relationship between the infertility rate and U. urealyticum, M. genitalium and M. hominis infections
From 2670 articles, we excluded further 1606 papers based on exclusion criteria (489 papers on M. genitalium, 595 papers on M. hominis, and 522 papers on U. urealyticum were excluded)
Summary
Many species of mycoplasmas regard as normal flora, but some species causes serious genital disease. In Iran several epidemiological studies have documented the prevalence of Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in genital disorders. Mycoplasma and Ureaplasma geniuses are the smallest self-replicating organism that belong to the Mollicutes class [1–4]. They live as external parasites of the human, animal, bird, insect and plant cells. U. urealyticum can be transmitted in different ways, including directly by sexual transmission, vertically from mother to offspring, or through transplanted tissues [8–13] Genital mycoplasmas such as M. hominis, M. genitalium and U. urealyticum are important emerging sexually transmitted bacterial pathogens capable to cause asymptomatic, long-term and chronic infection in genitourinary tract which is considered to be a threat to community health [14, 15]. About 40% of infants born from infected mothers with genital Mycoplasma infection had symptomatic infection such as neonatal conjunctivitis and meningitis by an ascending route or by crossing the placenta from the mother’s blood via delivery through a colonized birth canal [16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
