Abstract
BackgroundGastric cancer is actually known as the sixth most frequent cancer and the second cancer-related cause of death worldwide. If studies giving an overview of current epidemiology of gastric cancer in Europe, Asia, and the USA are available, in Africa, studies reporting recent data on gastric cancer are sparse. This systematic review and meta-analysis aim therefore to provide relevant data on contemporary epidemiology of gastric cancer in Africa in terms of prevalence, incidence, and case fatality rate.Methods and designWe will include cohort, case-control, cross-sectional studies, and case series with more than 30 participants. EMBASE, PubMed, Africa Index Medicus, Africa Journals Online, and Web of Science will be searched for relevant abstracts of studies published and unpublished between January 1, 2000, and April 30, 2019, without language restriction. The review will be reported according to the MOOSE (Meta-analysis Of Observational Studies in Epidemiology) guideline. After screening of abstracts, study selection, data extraction, and risk of bias assessment, we shall assess the studies individually for clinical and statistical heterogeneity. Random-effect meta-analysis will be used to pool studies judged to be clinically homogenous. The Egger test and visual inspection of funnel plots will be used to assess publication bias.DiscussionThis review will provide relevant data on the current burden of gastric cancer in Africa.Systematic review registrationPROSPERO CRD42019130348.
Highlights
Gastric cancer is known as the sixth most frequent cancer and the second cancer-related cause of death worldwide
Japan, which is between the ten countries with the highest prevalence of gastric cancer in the world, has contributed significantly to a better understanding of the Danwang and Bigna Systematic Reviews (2019) 8:276 pathogenesis of gastric cancer and the role of early endoscopic screening in the reduction of its prevalence [2, 7]
This systematic review and meta-analysis aim at the following: 1. Determine the incidence of gastric cancer in people living in Africa
Summary
Gastric cancer is known as the sixth most frequent cancer and the second cancer-related cause of death worldwide. Japan, which is between the ten countries with the highest prevalence of gastric cancer in the world, has contributed significantly to a better understanding of the Danwang and Bigna Systematic Reviews (2019) 8:276 pathogenesis of gastric cancer and the role of early endoscopic screening in the reduction of its prevalence [2, 7]. In this country, a 50% reduction in mortality rate associated with gastric cancer between 1975 and 2005 has been observed [2]
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