Abstract
Presenile Dementia or Early Onset Dementia (EOD) is a public health problem, it differs from Senile Dementia, and encloses a significant number of cases; nevertheless, it is still poorly understood and underdiagnosed. This study aims to review the prevalence and etiology of EOD, comparing EOD with Senile Dementia, as well as to show the main causes of EOD and their prevalence in population and non-population based studies. The computer-supported search used the following databases: Pubmed/Medline, ISI Web of Knowledge and Scielo. The search terms were alcohol-associated dementia, Alzheimer's disease, dementia, Creutzfeldt-jakob disease, dementia with lewy bodies, early onset dementia, frontotemporal lobar degeneration, Huntington's disease, mixed dementia, neurodegenerative disorders, Parkinson's disease dementia, presenile dementia, traumatic brain injury, vascular dementia. Only papers published in English and conducted from 1985 up to 2012 were preferentially reviewed. Neurodegenerative diseases are the most common etiologies seen in EOD. Among the general population, the prevalence of EOD was found to range between 0 to 700 per 100.000 habitants in groups of 25-64 years old, with an increasing incidence with age. The progression of EOD was found to range between 8.3 to 22.8 new cases per 100.000 in those aged under 65 years. Alzheimer's disease (AD) is the major etiology, followed by Vascular Dementia (VaD) and Frontotemporal Lobar Degeneration (FTLD). A larger number of epidemiological studies to elucidate how environmental issues contribute to EOD are necessary, thus, we can collaborate in the planning and prevention of services toward dementia patients.
Highlights
Dementia is an elderly disease, as it can affect young people
This study aims to review the prevalence and etiology of Early-Onset Dementia" (EOD), comparing EOD with Senile Dementia, as well as to show the main causes of EOD and their prevalence in population and non-population based studies
This study reported the prevalence of EOD of 83.3 per 100.000 for an age group 45-64 years whereas the prevalence for Alzheimer's disease (AD) for age groups from 25-64 and from 45-64 years was 10.6 and 22.3 per 100.000 respectively [27]
Summary
Dementia is an elderly disease, as it can affect young people. The term "Early-Onset Dementia" (EOD) or “Presenile Dementia" defines all dementia related conditions onset before 65 years of age [1, 2]. EOD is a heterogeneous group of cognitive disorders, but poorly understood, as the main focus of dementia is based on older populations, so EOD is more underdiagnosed, misunderstood, and inadequately treated, with limited services and resources in many countries [9, 10]. It can be perceived as a fatal disorder in which there is no cure and death appears before old age [11].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Clinical Practice & Epidemiology in Mental Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
