Epidemiology, Clinical Characteristics and Outcome of Acute Kidney Injury in Intensive Care Units of Alexandria University Hospitals

Abstract

1.1.Background: Acute kidney injury (AKI) considered as a major public health problem that affects millions of patients worldwide and leads to decreased survival and increased progression of chronic kidney disease (CKD). 1.2.Aim of study: Epidemiology, clinical characteristics and outcome of acute kidney injury in patients admitted to main Alexandria university hospitals over six months. 1.3.Methods:All patients who were admittedto intensive care units (ICUs) at Alexandria University Hospitals wereprospectively studied. Patients whodeveloped ICU-acquired acute renalfailure were collected in the period over six months. 1.4.Results:Our study included 500 patients in general ICU. General ICU patients classified according to renal impairment: 303 cases (no AKI) 60.6%, 74 cases (CKD) 14.8%, 55 cases (AKI) 11%, 38 cases (acute on top of CKD) 7.6%, 28 cases (ESRD) 5.6%, 2 cases (obstructive uropathy) 0.4%. Bimodal distribution of age in patients developed AKI at (18-30y) & (62-85y). 75 Toxicological cases, 3 developed AKI (2 organo phosphorus & 1 scorpion bite). The most common cause of AKI in our study was septic AKI 60% & among 128 cases of sepsis 32% not developed AKI/ 25.8% developed septic AKI 32% acute on top of CKD/10.2% ESRD. Mortality rate allover general ICU patients was 140/500 (28%) while allover AKI patients in general ICU 30/55(54%) and allover septic AKI 26/33(79%). 1.5.Conclusion:AKI is a worsening problem, but its true incidence is in need of huge work, our work was 1st up to our knowledge in Alexandria to check its incidence hence planning for better outcome.