Abstract
BackgroundIn last three years, 96 suspected poultry farms from different provinces in China were diagnosed for avian infectious bronchitis (IB) survey. Finally, 221 IBV strains were confirmed by dwarf embryo test and RT-PCR assay. By virus recovery trials, 187 of the isolates caused the birds died or distressed from nephritis, which was accordant with the clinical record.ResultsBased on epidemiology analysis of recent field isolates of nephropathogenic IB in vaccinated farms in China, YL6 strain were used for vaccination and evaluated by antibody titer and challenge tests. The immunoprotection test indicated that the practical application of vaccine based on the recent field strains could finely facilitate controlling the nephropathogenic IB.ConclusionsOur study was aim at setting a guide for safeguard against nephropathogenic IBV-caused disease in China.
Highlights
In last three years, 96 suspected poultry farms from different provinces in China were diagnosed for avian infectious bronchitis (IB) survey
Isolated infectious bronchitis virus (IBV) strains during 2008 to 2010 From unhealthy birds suspected of IBV infection in the vaccinated chicken farms from Guangdong, Guangxi, Fujian, Hainan, Jiangsu, Zhejiang, Chongqing, Hubei, Sichuan and Jiangxi province of China, 221 filed IBV strains isolated during 2008-2010 were confirmed by RTPCR, including 214 strains isolated from broilers, and 7 strains from broiler breeder
The clinical cases caused by vaccination failure raised the importance to investigate the circulating nephropathogenic IBVs and select the candidate vaccine strain against the infections [1,12]
Summary
96 suspected poultry farms from different provinces in China were diagnosed for avian infectious bronchitis (IB) survey. There is accumulating evidence that nephropathogenic type IB has been more and more prevalent in China recently, but the strains isolated in earlier years mainly caused respiratory signs, Some researchers reported that satisfactory cross protection could be provided by appropriate vaccine programs against genetically or antigenically unrelated IBVs [8]. This symphysial vaccine manner was restricted by the diversity of the IBV strains. The most possible explanation for this phenomenon may be that the vaccine effectiveness is diminished by poor cross-protection against the circulating strains
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