Abstract
BackgroundEvery year around the world, more than 2 million women are diagnosed with breast cancer and genital tract cancers. However, there are rare studies comprehensively describing the global and regional trends of incidence and mortality of women’s cancers.MethodsTo study the burden and trend of women’s cancers, we conducted this cross-sectional study based on the epidemiologic data of Global Burden of Disease 2019. In this study, female patients with breast cancer, cervical cancer, ovarian cancer, and uterine cancer worldwide from 1990 to 2019 were involved. The incidence, death, and disability-adjusted life-year (DALY) were used to measure the outcomes of women’s cancers. The estimated annual percentage change (EAPC) was calculated to assess the changing trend of cancer burden.ResultsAmong the four women’s cancers, the burden of female breast cancer was highest. During the past 30 years, the incidence, death, and DALY of female breast cancer kept increasing worldwide. In most regions especially developing countries, cervical cancer was the second most common women’s cancer. At the same time, ovarian cancer and uterine cancer occurred less frequently. Generally, the age-standardized incidence rates (ASIRs) of breast cancer, ovarian cancer, and uterine cancer were positively correlated to sociodemographic index (SDI) value. In contrast, the ASIR of cervical cancer was negatively correlated to SDI value.ConclusionsOur study indicates that the incidence and mortality of women’s cancers have geographical variations and change along with SDI value. The results might be helpful to policy-makers to allocate healthy resources to control women’s cancers.
Highlights
Every year around the world, more than 2 million women are diagnosed with breast cancer and genital tract cancers
A systematic analysis comprehensively reporting the variation trends of women’s cancers helps policymakers measure the burden of women’s cancer, build health service infrastructures, and allocate public health resources. In this cross-sectional study, we reported the incidences, deaths, and disability-adjusted life-years (DALYs) of female breast cancer, cervical cancer, ovarian cancer, and uterine cancer from 1990 to 2019 in 204 countries
Study Population and Data Collection All data were obtained from Global burden disease (GBD) 2019 study, including incidences, deaths, DALY, age-standardized rate of incidence (ASIR), age-standardized rate of death (ASDR), and age-standardized rate of DALY from 1990 to 2019
Summary
Every year around the world, more than 2 million women are diagnosed with breast cancer and genital tract cancers. According to GLOBOCAN 2020 Project data, breast cancer, cervical cancer, ovarian cancer, and uterine cancer are among the top 10 common cancers in females worldwide [1]. It is estimated that female breast cancer has been the most common cancer, surpassing lung cancer globally [1]. There are significant geographical variations in the incidence rate of female breast cancer [1]. Among females, breast cancer is the leading cause of cancer deaths in most countries [1]. In some sub-Saharan Africa countries, breast cancer is preceded by cervical cancer, which causes the most cancer deaths [1]. Ovarian cancer and uterine cancer occur less frequently globally [3,4,5]. The incidences and deaths of four types of women’s cancers have continued to grow during the past decades
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