Epidemiological Trend Analysis and Survival Data of Balinese with Soft-Tissue Sarcoma in 2015–2021

Abstract

BACKGROUND: Soft tissue sarcoma (STS) has a very heterogen features of its nature, subtypes, and clincial behaviour among population. Regardless, the epidemiology data of soft tissue sarcoma is very limited in developing countries, including Indonesia.
 AIM: To decribe the incidence and mortality trend analysis, as long as the survival data in Bali from 2015 to 2020.
 METHODS: This is a case control study including all subjects with STS in Denpasar, Bali, Indonesia from January 2015 to September 2021. Data about demographics, clinical, and survival timing data were collected from Cancer Registry. Soft tissue sarcoma diagnosis was confirmed after histopathological examination. Joinpoint regression was used for crude rate trend analysis. Data was analyzed by SPSS 22.0, using Kaplan-Meier for survival analysis.
 RESULTS: Ninety three subjects with STS were included in this study. Most patients died at the end of the study (65.6%) with median survival of only 30 months. The trend of STS age-standardized incidence and mortality rate was increasing from 2015 to 2018, then declining until 2020. The survival rate varies among the soft tissue sarcoma subtypes and location. It was better in the group without metastases, underwent therapy, but not statistically significant.
 CONCLUSION: Soft tissue sarcoma showed a diversity of demographic and clinical parameters. The incidence and mortality rate has plateued in 2018, but then declining. The survival rate diversed regarding of the STS subtype, location, metastasis, and treatment given.