Epidemiological survey of cervical cancer and human papilloma virus infection among women in Ningbo city

Abstract

Objective To explore the epidemiological characteristics of cervical cancer and human papillomavirus (HPV) infection in Ningbo. Methods The registration data from 2002 to 2014 were used for estimating the cervical cancer incidence and mortality in Ningbo. Community-based and hospital-based surveys were performed in married women to assess the HPV infection and risk factors. And Phylogenetic analysis of HPV16 E6 gene was performed. Results The crude incidence and the age-standardized incidence of cervical cancer by Chinese population and world population were 15.74/105, 11.29/105 and 10.05/105, respectively, and the incidence reached the top in female aged 45-50 years old. Meanwhile, the crude mortality of cervical cancer was 3.09/105, and the age-standardized rate by Chinese population and world population were 2.26/105 and 2.08/105, respectively. The prevalence rates of the high-risk genotypes of HPV among community-based women and female patients from local gynecological clinic were 16.2% and 18.3%, respectively. HPV52 was the most prevalent type (4.2%) in community-based women, followed by HPV 16 (3.0%), HPV58 (2.16%). HPV16 (4.9%), HPV52 (3.6%) and HPV58 (2.6%) were the top three prevalent types in gynecological patients. Phylogenetic analysis showed that Asian variants of HPV16 type were predominated and European variants were also detected in the infection cases. Conclusions The morbidity and mortality of cervical cancer closed to the general level of China in recent years, and HPV prevalence is relatively high in community women. This study provided useful information for mass vaccination to prevent cervical cancer in future. Key words: Cervical cancer; Human papillomavirus; Type distribution; Relevant factors