Epidemiological study on nosocomial infection after liver transplantation from organ donation after death

Abstract

Objective To investigate the epidemiological characteristics of nosocomial infection after liver transplantation from organ donation after death of citizens, and to provide evidence for the development of effective prevention and control strategies. Methods Targeted monitoring was conducted on liver transplantation patients in a hospital from January 1, 2014 to December 31, 2017, and then descriptive statistical analyses were carried out on postoperative infection after liver transplantation. Results The nosocomial infection occurred in 118 cases (55.40%) among 213 cases of liver transplantation. The infection sites were lower respiratory tract, blood system, and intra-abdominal infection, accounting for 40.30%, 22.39%, and 19.40%, respectively. 186 strains of pathogens were isolated, mainly including gram-positive cocci (including 113 strains, 60.75%), followed by gram-negative bacilli (56 strains, 30.11%) and fungi (17 strains, 9.14%). There was significant difference in the infection of the respiratory tract, post-operative wounds and other parts (P<0.05). The most common pathogens were Enterococcus faecium, Staphylococcus, Klebsiella Pneumoniae, and Stenotrophomonas maltophilia, accounting for 15.05%, 15.05%, 10.22% and 9.69%, respectively. There was significant difference in Gram-negative Bacillus, fungi strains, Acinetobacter strains, Enterococcus faecium strains, Pseudomonas aeruginosa strains, Stenotrophomonas maltophilia and staphylococcus (P<0.05). Conclusion The patients after liver transplantation from organ donation after death have a high incidence of nosocomial infection. The infection was mainly distributed in the lower respiratory tract and blood system, and predominantly caused by bacteria and fungi. Infection surveillance of liver transplant patients should be strengthened and comprehensively effective prevention and control measures for nosocomial infection should be developed. Key words: Liver transplantation; Nosomial infection; Epidemiological study