Abstract
Objective To investigate the levels of antibody to pertussis toxin (PT) IgG in newborns in Shunyi Women and Children's Hospital of Beijing Children's Hospital in 2016. Methods A total of 419 newborns were enrolled in this study. Umbilical cord blood sample was collected from each subject and detected by enzyme-linked immunosorbent assay to measure the concentration of PT-IgG. Besides, all newborns were followed up to January 31, 2017. Chi-square test was used for statistical analysis. Results The detectable rate of umbilical cord blood samples for PT-IgG accounted for 30.1% (126/419). The median antibody level was <5 U/ml, and the 90th and the 95th percentile were 14.3 and 24.0 U/ml, respectively. No cases of pertussis occurred at the end of follow-up. Conclusions The newborns born in Shunyi Women and Children's Hospital of Beijing Children's Hospital are generally lack of protective PT antibody. Key words: Pertussis toxin; Immunoglobulin G; Whooping cough; Fetal blood; Epidemiologic studies; Infant, newborn
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