Abstract
Introduction. Acinetobacter baumannii is a pathogen and a major cause of nosocomial infections in the current healthcare system worldwide due to its high resistance to antibiotics, including those considered as a last resort, thus posing threat to severe clinical forms, as well as exhibiting significant economic and clinical impact.
 Material and methods. A descriptive longitudinal and cross-sectional epidemiological study was carried out based on the model of multidisciplinary care hospitals.
 Results. The generalized clinical forms of Acinetobacter nosocomial infections predominate in 56.30%, including: pulmonary sepsis – 25.59%, abdominal sepsis – 11.81%, septicemia – 9.45%, wound sepsis– 6.30%, biliary sepsis – 1.97%, and urosepsis – 1.18% of cases. Local infections were found in 16.93% of wound infections and in 14.57% of pneumonia cases. A. baumanii was present in the etiological structure of 98.18% of cases, exhibiting an increased resistance to antibiotics, particularly to monobactams – 100.0%, macrolides – 98.82%, penicillins – 98.08%, cephalosporins – 97.65%, penicillins with beta-lactamase inhibitors – 93.20%, fluoroquinolones – 87.16%, and amphenicols – 84.17% of cases. A. baumanii strains isolated from patients with nosocomial infections were found to be multidrug resistant to antibiotics in 93.08% of cases. 
 Conclusions. Acinetobacter baumannii nosocomial infections represent a major public health issue that requires the implementation of strict surveillance and control strategies, including the rational use of antibiotics.
Highlights
EPIDEMIOLOGICAL STUDY OF ACINETOBACTER BAUMANNII NOSOCOMIAL INFECTIONS Introduction
Acinetobacter baumannii is a pathogen and a major cause of nosocomial infections in the current healthcare system worldwide due to its high resistance to antibiotics, including those considered as a last resort, posing threat to severe clinical forms, as well as exhibiting significant economic and clinical impact
A. baumanii was present in the etiological structure of 98.18% of cases, exhibiting an increased resistance to antibiotics, to monobactams – 100.0%, macrolides – 98.82%, penicillins – 98.08%, cephalosporins – 97.65%, penicillins with beta-lactamase inhibitors – 93.20%, fluoroquinolones – 87.16%, and amphenicols – 84.17% of cases
Summary
Acinetobacter baumanii prezintă un agent patogen ce cauzează infecții nosocomiale, devenind, actualmente o amenințare globală de sănătate publică din cauza nivelurilor ridicate de rezistenţă la antibiotice, inclusiv la cele considerate de ultimă instanță, formelor clinice severe, impactului economic şi clinic semnificativ. A. baumannii este cea mai importantă specie din punct de vedere clinic, fiind responsabilă de 80% dintre infecțiile cauzate de microorganismele din genul Acinetobacter, considerat și unul dintre principalii agenți cauzali ai infecțiilor nosocomiale la zi. Acinetobacter baumannii a fost clasificat în grupul critic ca cel mai primejdios grup de bacterii multirezistente (MDR), – la cefalosporine de generația a treia și carbapeneme, și pentru care sunt necesare urgent antibiotice noi [9,10,11,12,13]. Scopul studiului: de a determina situația epidemiogenă reală prin infecțiile cu Acinetobacter creată în Republica Moldova în baza modelului spitalelor multiprofil
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