Abstract
Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa. Epidemiology data regarding mucosal melanomas in Brazil is scarce, hence the motivation to conduct this research paper. The χ2 test was used to compare categorical variables. Forward stepwise logistic regression method was used in the multivariate analysis to identify independent predictors of early death. A total of 801 patients were included in the analysis. Surgical resection is frequently the first approach to primary tumours (65.3%), even though the utility of lymph node surgery and radiation therapy is not well established. Advanced stage was observed in more than two thirds of patients. Early death was observed in 28.3%. MM cases with regional or distant metastases as well as those located in unusual locations had almost 4 times more risk for early death. Besides that, MM located in lips, oral cavity and pharynx and those receiving chemotherapy had 2 times more risk of early death.
Highlights
Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa
Mucosal melanoma (MM) is a primary malignant neoplasia originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, the head and neck region, followed by anorectal mucosa and vulvovaginal mucosa[1,2,3]
Notwithstanding, Ascierto and collaborators believe that the advances in melanoma treatment, especially related to the new discoveries on the scope of the molecular profile of these tumours, boosted the optimism when it comes to the possibility of more effective systemic therapies available[5]
Summary
Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa. Mucosal melanoma (MM) is a primary malignant neoplasia originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, the head and neck region, followed by anorectal mucosa and vulvovaginal mucosa[1,2,3]. Notwithstanding, Ascierto and collaborators believe that the advances in melanoma treatment, especially related to the new discoveries on the scope of the molecular profile of these tumours, boosted the optimism when it comes to the possibility of more effective systemic therapies available[5]. The purpose of this research was to fill this gap clarifying the scientific community about the epidemiological characteristics of MM in the country with special emphasis on MM’s early death predictors
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
