Abstract

Background:Thalassemia is an inherited disorder of haemoglobin production resulting from unbalanced haemoglobin synthesis. Thalassemia is predominantly a disease of children. Material and Methods :This study was conducted on 100 patients of thalassemia major registered in PBM and associated group of hospitals,Bikaner in the years 2019 and 2020.Analysis of epidemiology and PBF abnormalities of the patients was done. Results :It was found that maximum number of patients were in 0 to 5 years age group.Maximum frequency was in B positive age group,Hindu:Muslim ratio was 63:37 and male:female ratio was 54:46.PBF showed anisocytosis and poikilocytosis of RBC with microcytic hypochromic anemia,target cells and NRBCs as the main anomalies.White cells and platelets were normal in majority of cases. Conclusion:Knowledge of epidemiological prole aids in implementation of screening and control programmes. PBS examination is an early,cost-effective investigation in the initial diagnosis of thalassemia.

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