Abstract
Introduction: Multiple Sclerosis (MS) is a chronic, autoimmune and progressive pathology, is it the primary demyelinating disease of the nervous system and the most frequent in the world. Therefore, becomes relevant set the epidemiological profile of MS in Brazil aiming to understand hospitalization dynamics and evolution of disease. Objective and Methods: To analyze epidemiological profile hospitalization for MS in Brazil, from 2015 to 2019. An epidemiological, retrospective, descriptive study was realized through the Hospital Information System (SIH/SUS/ DATASUS), from 2015 to 2019. Categories used: sex, color/race and age group. It is not required appreciation by the Research Ethics Committee for using publics information, without identifying the participants. Results: In Brazil, from 2015 to 2019, 18.536 hospitalizations happened for MS, having growth from 2015 (n=2.083) to 2018 (n=4.755), with a decrease in 2019 (n=4.021). Southeast had higher percentual (66,98%, n=12.416), South (13,95%, n=2.585), Midwest (10,65%, n=1.965), Northeast (6,42%, n=1.190) and North (2%, n=370). The most of hospitalization it is in the age of 20 to 49 years (75%, n=13.892), with prevalence in females (69,8%, n=12.941), over males (30,2%, n=5.595) and proportion 2,31W:1M. White color is majority (53,7%, n=9.951), grayish-brown (24,8%, n=4.597) and indigenous people (0.005%, n=1). Conclusion: It was realized prevalence of hospitalization in women, of color white, age between 20-49 years, from Southeast. It urgent the importance of investigation, forward diagnostic and treatment of that pathology in country, to try decrease to the maximum injury affected population.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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