Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn’s disease

Abstract

Background-AimsThe SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn’s disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability. MethodsThe following tools were used over 12 months to assess:•disease-related worries: Rating Form of Inflammatory Bowel Disease Patient Concerns,•impact on workability: Work Productivity and Activity Impairment-CD,•satisfaction: Treatment Satisfaction Questionnaire for Medication,•adherence: Medication Adherence Rating Scale.Results were correlated with demographic and clinical variables with linear regression models. Results552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001). ConclusionWorries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.