Abstract
A total of 126 patients were included in the study- 65 girls and 61 boys. The mean age of the subjects was 8 ± 4 years (ranging from three to sixteen years). The most represented age group was that from 3-4 years of age. Most of the participants were from the Central Region (46%). All of the subjects were homozygous for hemoglobin SS. Subjects with yearly frequency of three vaso-occlusive crises represented 42.9% of the sample. 57.9% of the patients had been polytransfused within the past 3 years (>2 transfusions). Up to 45.2% of the patients had been hospitalized within the past year.
Highlights
Sickle-cell anemia (SCA) is a hereditary hemoglobinopathy characterized by the presence of hemoglobin S inside red blood cells [1]
This motivated us to carry out this study with the main aim of describing and analyzing the socio-demographic, clinical and biological characteristics of Cameroonian children and adolescents with sickle-cell anemia
The divergence of these results shows that SCA is a hereditary disease of autosomal transmission, which means the anomaly is not sexrelated
Summary
Sickle-cell anemia (SCA) is a hereditary hemoglobinopathy characterized by the presence of hemoglobin S inside red blood cells [1]. SCA manifestations can affect all tissues with slow blood circulation They involve cranio-facial bones and the mouth where the most described manifestations include gingival hypertrophy, periodontal disease, dental caries, pulp necrosis and tonsillar hypertrophy, and a light-pink coloration of the mucosa [5,6,7]. In Cameroon, bucco-dental manifestations of SCA are not well-known owing to the paucity of studies carried out on these subjects This motivated us to carry out this study with the main aim of describing and analyzing the socio-demographic, clinical and biological characteristics of Cameroonian children and adolescents with sickle-cell anemia
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