Epidemiological characteristics of bloodstream infection in patients with somatic diseases

Abstract

In 1999, at the conference of the European Working Group on Nosocomial Infections, the term "bloodstream infection" was proposed in the presence of clinical symptoms and microorganisms in the bloodstream. The first classification of bloodstream infection consisted of 3 categories: hospital, iatrogenic and out-of-hospital. Then theywere classified into 5 categories. At the same time, bloodstream infection that occurred during the first 48 hours after the patient's admission to the medical organization were divided into 4 groups (AD). "Group C" included bacteremia associated with invasive procedures and was classified into 5 subgroups.
 The number of episodes of IR. The number of episodes of bloodstream infection in the world is growing depending on the geographical location of the country (from 1995 to 2002 increased by 40%, by 2007 ― by 14.3%). Among the sources of infection, the role of the respiratory, hepatobiliary, gastrointestinal, urogenital and urinary tracts, the presence of intravascular devices and pneumonia. Bloodstream infection is characterized by frequent infestation of men, staphylococcal etiology, catheter-association, and the presence of comorbid diseases. Re-episodes of Gram-negative bloodstream infection are more likely to occur within 3 months. Until 2004, Staphylococcus aureus was the leading pathogen of bloodstream infection; after 2005, Escherichia coli dominated.
 These two pathogens succeeded each other in different years. Currently, pathogens of bloodstream infection in patients with therapeutic profile are gram-positive cocci, including CNS, S. aureus, enterococci, fungi and anaerobes. Bloodstream infection is characterized by polymicrobiality (35.7%), including bacterial-fungal (22%).