Abstract
BackgroundThis study aimed to assess the associations of serum uric acid (SUA) levels and hyperuricemia with cardiometabolic risk factors in a Chinese community-dwelling population.MethodsA large cohort of 4706 residents was enrolled in this study. Physical examinations and laboratory tests were performed following a standardized protocol. Multiple linear and logistic regression analyses were conducted with adjustment of cardiometabolic risk factors including age, sex, body mass index (BMI), blood pressure (BP), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c) and fasting blood glucose (FBG) levels using SPSS version 17 software.ResultsThe prevalence of hyperuricemia was 7.6 %. There were significant differences in age, BMI, BP, TG, HDL-c, LDL-c and FBG levels and the proportion of men between participants with and without hyperuricemia. Multiple linear regression analysis showed that SUA levels were positively associated with age, sex, BMI, BP, TG and LDL-c levels, but negatively associated with HDL-c and FBG levels. Multiple logistic regression analysis showed that per unit increase in age was associated with a 1.014 times higher odds of the presence of hyperuricemia. Men had a 1.858 times higher odds of the presence of hyperuricemia compared with women. Per unit increases in BMI, BP, TG and LDL-c levels were associated with 1.103, 1.016, 1.173 and 1.200 times higher odds of the presence of hyperuricemia, respectively. Per unit increases in HDL-c and FBG levels were associated with 0.616 and 0.900 times lower odds of the presence of hyperuricemia, respectively.ConclusionsIn a Chinese community-dwelling population, age, sex, BMI, BP, TG, HDL-c, LDL-c and FBG levels are cardiometabolic risk factors that are significantly associated with SUA levels, as well as the presence of hyperuricemia.
Highlights
This study aimed to assess the associations of serum uric acid (SUA) levels and hyperuricemia with cardiometabolic risk factors in a Chinese community-dwelling population
We conducted a comprehensive study involving a large cohort of Chinese community-dwelling population to assess the potential associations of SUA levels and hyperuricemia with cardiometabolic risk factors
Multiple linear regression analysis showed that SUA levels were positively associated with age, sex, body mass index (BMI), Pulse pressure (PP), TG, and low-density lipoprotein-cholesterol (LDL-c) levels, but negatively associated with high-density lipoprotein-cholesterol (HDL-c) and fasting blood glucose (FBG) levels
Summary
This study aimed to assess the associations of serum uric acid (SUA) levels and hyperuricemia with cardiometabolic risk factors in a Chinese community-dwelling population. Serum uric acid (SUA) is an end product of purine catabolism in humans and higher primates. In parallel with rapid development of cardiometabolic risk factors, including aging, obesity, high blood pressure (BP), lipids and glucose, the prevalence of hyperuricemia is rising in developing and developed countries [1, 2]. Elevated levels of SUA are associated with increased cardiovascular morbidity and mortality in subjects who already. Fu et al BMC Cardiovascular Disorders (2015) 15:129 studies in Chinese community-dwelling population on the associations between SUA levels and cardiometabolic risk factors are scarce [6]. We conducted a comprehensive study involving a large cohort of Chinese community-dwelling population to assess the potential associations of SUA levels and hyperuricemia with cardiometabolic risk factors,
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