Abstract
Relevance: GLOBOCAN 2019 reports that colorectal cancer (CRC) ranks third among mortality
 causes and forth among the new diagnosed cases
 in the world. CRC incidence is growing worldwide
 and in the Republic of Uzbekistan. Thus, in the Republic of Uzbekistan CRC ranks fifth in the general
 cancer structure and second in men.
 The purpose of the study was to assess of global trends in CRC epidemiology and the CRC incidence in the Republic of Uzbekistan in 2018-2019.
 Results: Global CRC incidence and mortality
 trends varied by territory and level of economic development. Gender differences were also revealed:
 CRC was more common in men (1.25:0.8).
 Conclusions: An upward trend in CRC incidence revealed in the study of CRC oncoepidemiological situation in the Republic of Uzbekistan determines the need for further studies of territorial differences and the search for CRC occurrence
 factors
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