Abstract
Bladder carcinoma (BC) is one of the most common malignancies of the urinary system in developed countries, and it is also characterized by a high number of recurrences and progression rates despite multimodal treatment. BC is a biological and clinically heterogeneous tumor with a great propensity of divergent differentiation. Around the world, bladder cancer is responsible for 549.000 new cases и 200.000 deaths each year. In Bulgaria, bladder carcinoma is the 18th most common neoplasia. Our results on 105 proven bladder carcinoma cases confirmed that this tumor arises at 70 years at average (60-90 years), it affects men predominantly and there was no difference regarding the nationality of patients. In conclusion, it remains a diagnostic challenge.
Highlights
Urothelial bladder cancer is a common disease that takes the 9th rank in worldwide cancer incidence (Ploeg et al, 2009)
The analyzed 105 patients in our study were diagnosed with proven urothelial carcinoma
We must clarify that we included a few cases of urothelial carcinoma of renal pelvis and ureter
Summary
Urothelial bladder cancer is a common disease that takes the 9th rank in worldwide cancer incidence (Ploeg et al, 2009). The incidence of bladder cancer is three times greater in males than in females (Hartge et al, 1990). These differences in gender prevalence explained largely by differences in exposure to certain risk factors. In Western countries, smoking is responsible for around 50% of urothelial bladder cancer in males and 35% in females (Ploeg et al, 2009). The third most important risk factor for bladder cancer development is occupational exposure, as chronic exposure to arsenic
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