Epidemiological and clinical profile of novel coronavirus disease (COVID 19) in a hospital in Metropolitan India

Priti Chowdhary Priti Chowdhary,Deepika Govil Deepika Govil,Cecil C Khakha Cecil C Khakha,Munesh Kasana Munesh Kasana,Deepika C Khakha Deepika C Khakha,Ritesh Ranjan Ritesh Ranjan

doi:10.30574/wjarr.2020.8.1.0370

Priti Chowdhary Priti Chowdhary, Deepika Govil Deepika Govil + Show 4 more

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https://doi.org/10.30574/wjarr.2020.8.1.0370

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Abstract

Context: To understand the epidemiological and clinical profile of COVID 19. Aims: To study the epidemiological and clinical profile of Novel Coronavirus disease with comorbidities and outcome. Settings and Design: In this single centre study, we included patients with suspected and confirmed cases of COVID 19 Methods and Material: We followed the testing criteria for COVID 19 laid down by Ministry of Health and Family Welfare (MoHFW), Government of India. COVID 19 positive patients were divided as mild, moderate and severe and followed till discharge or death. Data was collected through interview of patients and hospital records. Results: A total of 178 suspected cases of COVID 19 reported to our hospital in this duration. Out of these, confirmed positive cases were 66 in number. Among 66 COVID 19 positive patients 11 were Health Care Workers. The Median age of the patients was 37 years. Most of the confirmed COVID patients were young and middle aged between 15 to 49 years age (69.69 %). 66.66 % were males and 33.33% were females. Case fatality rate was 4.54%. In our study only 15.15% had history of contact with COVID 19 positive patients. Conclusions: Fever is the most common presenting symptom but fever should not be the exclusion criteria. Since there is silent spread of virus in the community among the asymptomatic patients there is need to increase the number of testing. Containment and mitigation strategy like Social distancing should be maintained. Routine screening of Health Care Workers should be done.

Highlights

The most researched coronaviruses are Infectious Bronchitis Virus (IBV), Mouse Hepatitis Virus (MHV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). [1] These particles are enveloped, 80- to 220-nm particles containing unsegmented genome of single stranded positive sense RNA
Since there is silent spread of virus in the community among the asymptomatic patients there is need to increase the number of testing
Any person who presented with Severe Acute Respiratory Infection (SARI) AND any one of the following i.e. A history of travel from Wuhan, China in 14 days prior to symptoms onset; Disease in healthcare worker working in environment of SARI patients; Unusual or unexpected clinical course, especially sudden deterioration despite appropriate treatment; were to be urgently investigated

Summary

Introduction

The most researched coronaviruses are Infectious Bronchitis Virus (IBV), Mouse Hepatitis Virus (MHV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). [1] These particles are enveloped, 80- to 220-nm particles containing unsegmented genome of single stranded positive sense RNA [1] These particles are enveloped, 80- to 220-nm particles containing unsegmented genome of single stranded positive sense RNA These have the largest genomes known [around 30 kilobases (kb)] among RNA viruses.[2] Coronaviruses are host specific and cause respiratory diseases and Gastrointestinal diseases.[3] Recently identified SARS-CoV 2 (Novel Coronavirus 2019) is the causative agent of SARS.[4] WHO reported SARS-CoV2 on 31st December 2019. WHO declared COVID 19 a global pandemic on March 11, 2020. It is first pandemic since declaring H1N1 influenza a pandemic in 2009.[5]

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