Abstract
To investigate the early epidemic of COVID-19, a total of 176 confirmed COVID-19 cases in Shiyan city, Hubei province, China were surveyed. Our data indicated that the rate of emergence of early confirmed COVID-19 cases in Hubei province outside Wuhan was dependent on migration population, and the second-generation of patients were family clusters originating from Wuhan travelers. Epidemiological investigation indicated that the reproductive number (R0) under containment strategies was 1.81, and asymptomatic SARS-CoV-2 carriers were contagious with a transmission rate of 10.7%. Among the 176 patients, 53 were admitted to the Renmin Hospital of Hubei University of Medicine. The clinical characteristics of these 53 patients were collected and compared based on a positive RT-PCR test and presence of pneumonia. Clinical data showed that 47.2% (25/53) of COVID-19 patients were co-infected with Mycoplasma pneumoniae, and COVID-19 patients coinfected with M. pneumoniae had a higher percentage of monocytes (P < 0.0044) and a lower neutrophils percentage (P < 0.0264). Therefore, it is important to assess the transmissibility of infected asymptomatic individuals for SARS-CoV-2 transmission; moreover, clinicians should be alert to the high incidence of co-infection with M. pneumoniae in COVID-19 patients.
Highlights
By the end of 2019, just before the Chinese New Year, an outbreak of idiopathic pneumonia surfaced in Wuhan, China (Li Q. et al, 2020)
The same trend of newly confirmed cases was found in Shiyan city, with a peak of 44 cases that fluctuated between February 2 and February
Because computed tomography (CT)-based diagnosis of COVID-19 was considered a confirmatory criterion in Hubei province [Diagnosis Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 6, Revised), World Health Organization (WHO) China Office, 2020], more than 10,000 patients were treated in hospital on February 12, 2020 (Lu J. et al, 2020)
Summary
By the end of 2019, just before the Chinese New Year, an outbreak of idiopathic pneumonia surfaced in Wuhan, China (Li Q. et al, 2020). The causative pathogen was identified as a novel coronavirus With rapidly increasing clinical cases, person-to-person transmission was confirmed (Chan et al, 2020b). This novel coronavirus was later named by the International Committee on Taxonomy of Viruses as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) (Coronaviridae Study Group of the International Committee on Taxonomy of Viruses, 2020). On January 30, 2020, a public health emergency of international concern was declared by the World Health Organization (WHO) (Public Health Emergency of International Concern declared by WHO, 2020). By March 30, 2020, a total of 82,545 coronavirus
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