Abstract
IntroductionDementia is a real fact in the course of Human Immunodeficiency Virus infection. In Mali, no specific studies have been done to estimate its frequency. The objective of this study is-to evaluate the frequency of Human Immunodeficiency Virus associated dementia at the university hospital of Point G-to assess the clinical profile and the risk factors of Human Immunodeficiency Virus associated dementia at the university hospital of Point GMethodsIt is a prospective study design extended from July 2009 to August 2010. 113 Human Immunodeficiency Virus positive patients aged 16 years old and plus have been recruited from the department of neurology, the infectious disease department and the emergency department at the university hospital of Point G. Data was collected using clinical evaluation reporting forms. Patients were interviewed and evaluated using the international HIV dementia scale. The international HIV dementia scale total score is 12. A score less or equal to 10 is considered to be abnormal and may indicate HIV associated dementia.Results Using the International HIV Dementia Scale, we found a significant frequency of dementia; 69.9%. Advanced clinical state, low CD4 count, AIDS stage, low level of education and the decline of the activity of daily life, were the risk factors significantly associated with Human Immunodeficiency Virus dementia.ConclusionThe International Human Immunodeficiency Virus Dementia Scale is a screening toll for dementia in HIV-infected patient. 69.9% of the HIH positive patients were demented with a score less or equal to 10. Its adaptation is socio-culturally convenient in Mali
Highlights
Introduction Dementia is a real fact in the course of Human Immunodeficiency Virus infection
The objective of this study is -to evaluate the frequency of Human Immunodeficiency Virus associated dementia at the university hospital of Point G
Using the International HIV Dementia Scale, we found a significant frequency of dementia; 69.9%
Summary
Dementia is a real fact in the course of Human Immunodeficiency Virus infection. In Mali, no specific studies have been done to estimate its frequency. The objective of this study is -to evaluate the frequency of Human Immunodeficiency Virus associated dementia at the university hospital of Point G. -to assess the clinical profile and the risk factors of Human Immunodeficiency Virus associated dementia at the university hospital of Point G Methods It is a prospective study design extended from July 2009 to August 2010. Si l’on observe une diminution de l’incidence des infections opportunistes, force est de constater que la prévalence des troubles cognitifs mineurs précèdent la démence liée à l’infection par le VIH reste inchangée, voire augmente du fait de la longévité des patients et de l’efficacité insuffisante des antirétroviraux sur la neurotoxicité induite par la réplication virale [1,5]. En Afrique sub-sahariennes, les études réalisées ont établi la fréquence des troubles cognitifs dus au VIH entre 5% et 31%[9]. Les études au Cameroun ont établi une fréquence de 6,60%[10] , celle de la République
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