Abstract
In villages with high incidence of endemic nephropathy (EN) from Vratza district. Bulgaria, an increased relative risk towards development of urinary system tumors (UST), in particular kidney pelvic and ureteral tumors (KPUT), was observed. The highest values of 28.3 fold for UST and 88.8 fold for KPUT were recorded for the population group affected by EN after an age standardization of the data: among residents not affected by EN of the same endemic villages the risk was 4.3 and 6.7 fold. For all tumors other than UST the relative risk varies between 0.74 and 1.5 fold.
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