Abstract
WHEN a clinician is consulted by a patient who formerly lived in an epidemic typhus zone and who now has fever, headache and possibly a rash, he must include Brill's disease in his differential diagnosis.1 , 2 The confirmation or elimination of the diagnosis of Brill's disease depends on the use of the complement-fixation test with epidemic typhus antigen.1 , 3 The interpretation of the results of the complement-fixation test is influenced by Zinsser's concept,4 which postulates that a patient with Brill's disease has previously suffered an attack of louseborne typhus fever. This hypothesis has been considerably strengthened by recent studies.1 2 3 Anyone suspected of . . .
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