Epidemic investigation of benign prostatic obstruction with coexisting overactive bladder in Shanghai Pudong New Area and its impact on the health-related quality of life

Qing-Tong Yi,Min Gong,Ru-Jian Zhu,Wei Hu,Chu-Hong Chen

doi:10.1186/s12894-019-0513-1

Qing-Tong Yi, Min Gong + Show 3 more

Open Access

https://doi.org/10.1186/s12894-019-0513-1

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Journal: BMC Urology	Publication Date: Sep 3, 2019
Citations: 1	License type: open-access

Affiliation: Pudong Medical Center, Fudan University

Abstract

BackgroundWe aimed to investigate the prevalence, relative risk factors, and the impact on the health-related quality of life (HRQoL) of benign prostatic obstruction (BPO) with coexisting overactive bladder (OAB) in men aged over 50 and living in Shanghai Pudong New Area.MethodsUsing a multi-stage sampling and descriptive epidemiological method, 1632 men were selected from among the general population. Participants completed an evaluation of lower urinary tracts symptoms (LUTS), including international prostate symptom score (IPSS) and quality of life (QoL) questionnaires. Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5) questionnaire. In addition, the Overactive Bladder Symptom Score (OABSS) and King’s health questionnaire (KHQ) were used to assess the impact of BPO with coexisting OAB on the HRQoL. Maximum flow rate (Qmax), postvoid residual urine volume (PVR) and prostate-specific antigen (PSA) were also recorded.ResultsA total of 1476 men with complete data were analyzed. The overall prevalence of BPO with coexisting OAB was 39.6%. Age and prostate volume were associated risk factors for BPO with coexisting OAB. In addition, BPO with coexisting OAB negatively impacted the HRQoL, with increased IPSS, QoL, OABSS, and KHQ scores and decreased IIEF-5 scores compared to that in patients with BPO without OAB.ConclusionsQmax, PVR and serum PSA did not predict whether the patients had a combined BPO + OAB or not. The prostate volume and age were associated risk factors for BPO with coexisting OAB. BPO is a progressive disease and may be one of the risk factors for OAB.

Highlights

We aimed to investigate the prevalence, relative risk factors, and the impact on the health-related quality of life (HRQoL) of benign prostatic obstruction (BPO) with coexisting overactive bladder (OAB) in men aged over 50 and living in Shanghai Pudong New Area
General characteristics of the study population and prevalence of BPO with coexisting OAB A total of 1632 participants were recruited from 10 subdistricts or towns in Shanghai Pudong New Area during October 2012 to September 2016
lower urinary tracts symptoms (LUTS) have traditionally been related to bladder outlet obstruction (BOO), which is often caused by benign prostatic enlargement (BPE) resulting from the histologic condition of benign prostatic hyperplasia (BPH)

Summary

Introduction

We aimed to investigate the prevalence, relative risk factors, and the impact on the health-related quality of life (HRQoL) of benign prostatic obstruction (BPO) with coexisting overactive bladder (OAB) in men aged over 50 and living in Shanghai Pudong New Area. Benign prostatic obstruction (BPO) is one of the most common urinary disorders leading to lower urinary tracts symptoms (LUTS) in middle-aged and elderly men. Overactive bladder (OAB) features urinary urgency, usually with frequency and nocturia, and with or without urge urinary incontinence [1, 2]. BPO commonly coexists with OAB and decreases the QoL in men. The following factors should be considered in the study of patients with lower urinary tract function: observations of patients (symptoms), quantification of symptoms, physician’s observations (anatomy, function and compliance), QoL measures, and socioeconomic evaluations [3].

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