Abstract
Abstract METHODS: The heating profile of MIONPs was assessed in the test tube and mouse brain in vivo. Computed tomography scan and magnetic particle imaging were used to confirm intracranial MIONP localization after convection enhanced delivery. Cell viability assays were performed following treatment with MHT and/or radiation. MHT-induced alterations to the tumor microenvironment were assessed in a syngeneic murine glioma model, and a survival study was performed in a GBM patient-derived xenograft (PDX) model to investigate synergism between MHT and CRT.
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