Abstract
Journal of Unexplored Medical Data is an open access journal, which considers well-conducted medical science studies, including clinical trials, pilot studies, research reports, original articles, reviews and short communications in the field of medical science.
Highlights
Treatment effectiveness in acute myeloid leukemia (AML) remains unsatisfactory because of frequent relapses and treatment-related problems in elderly patients, in whom AML incidence is relatively high compared to that in younger people[1,2]
Curcumin (80.1% purity), (-)-epicatechin, quercetin, fetal bovine serum (FBS), phosphate-buffered saline (PBS), ethanol, formaldehyde, dimethyl sulfoxide (DMSO), propidium iodide, and RNAse A were purchased from Sigma-Aldrich Co. (St Louis, MO, USA)
The investigated polyphenols can be sequentially ranked by cytotoxic activity as: curcumin > quercetin > epicatechin [Figures 1-3]
Summary
Treatment effectiveness in acute myeloid leukemia (AML) remains unsatisfactory because of frequent relapses and treatment-related problems in elderly patients (age > 65), in whom AML incidence is relatively high compared to that in younger people[1,2]. Researchers are still on a quest for new, more effective, and safer therapies for the treatment of AML, in elderly patients in whom aggressive chemotherapy for leukemia may sometimes be impossible (e.g. due to age-related comorbidities)[1]. Curcumin inhibits multiple pathways on different levels that are often overexpressed in cancer cells and sensitizes them to apoptosis; in cancer cells resistant to apoptosis, curcumin can induce an alternative cell death, such as a mitotic catastrophe[8,9,10]. It inhibits genes contributing to multidrug resistance and can modulate epigenetic phenomena by inhibiting the methyltransferase 1 in AML cells[13,14]
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