Abstract
Rationale: The epicardium is the primary source of cardiac fibroblasts, which secrete scar tissue following a myocardial infarction (MI). Serum response factor (SRF) and the SRF co-activators myocardin-related transcription factors (MRTFs) are required for epicardium-derived progenitor cell (EPDC) mobilization during development. However, the description of key transcriptional programs that regulate epicardium-derived fibrosis in adult cardiac disease requires further investigation.
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