Abstract
BackgroundSeveral studies have been performed to investigate the relationship between psoriasis and epicardial fat tissue (EFT). However, the number of patients of every single study is relatively small.ObjectivesWe carried out a meta-analysis to evaluate whether EFT is associated with psoriasis.MethodsA search of PubMed, Ovid Embase, Ovid Medline, the Cochrane Library and Chinese BioMedical Literature Database (CBM) for controlled trials was done from inception to January 20th, 2016. Published trials that included a psoriasis group and a control group without psoriasis with data for at least epicardial fat tissue (EFT) were included. All statistical analyses were conducted using the Stata 12.0 (Stata Corporation, College Station, TX, USA).ResultsThere were 5 trials involving 731 patients. Patients with psoriasis showed significantly higher EFT than control group (SMD: 0.86, 95 % CI: 0.27-1.46, P = 0.004).ConclusionsPatients with psoriasis have higher EFT compared to control subjects without psoriasis.
Highlights
Several studies have been performed to investigate the relationship between psoriasis and epicardial fat tissue (EFT)
This study showed that traditional risk factors for coronary heart disease such as diabetes, hypertension, hyperlipidemia, obesity and smoking are highly correlated with psoriasis
That may be caused by differences in measurement technology. In conclusion, this meta-analysis has demonstrated that there is no significant difference in total cholesterol, lowdensity lipoprotein (LDL), high-density lipoprotein (HDL) or triglycerides between psoriasis and control, but higher EFT in psoriasis group compared to control group
Summary
Several studies have been performed to investigate the relationship between psoriasis and epicardial fat tissue (EFT). Objectives: We carried out a meta-analysis to evaluate whether EFT is associated with psoriasis. Published trials that included a psoriasis group and a control group without psoriasis with data for at least epicardial fat tissue (EFT) were included. Patients with psoriasis showed significantly higher EFT than control group (SMD: 0.86, 95 % CI: 0.27-1.46, P = 0.004). Psoriasis is a chronic immune-mediated inflammatory disease which affects 2–4 % of the population worldwide [1]. It is characterized by sharply demarcated erythematous plaque lesions with silvery white scales. We play a meta-analysis to evaluate whether EFT is associated with psoriasis
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