Ephedrine versus phenylephrine effects on fetal outcome and hemodynamics of pre-eclamptic mothers undergoing cesarean section under spinal anesthesia

Abstract

Background This randomized double-blind study was started with an objective of comparing two commonly used vasopressors (phenylephrine and ephedrine) as intravenous bolus injection to reduce hypotension in elective cesarean section in mothers with pre-eclampsia and estimating their impact on fetal outcome. Place of the study The study was conducted in Woman Health Hospital, Assiut University, Egypt. Patients and methods We studied 40 pre-eclamptic patients undergoing elective cesarean section under spinal anesthesia who developed hypotension after subarachnoid block. They were randomly allocated to one of the two groups to receive an intravenous bolus of the following drugs: group P, phenylephrine (75 μg, n = 20) or group E, ephedrine (6 mg, n = 20). Hypotension was defined as a decrease in systolic pressure to more than 25% of baseline values or systolic blood pressure of less than 90 mmHg. Results There were significant differences in systolic and diastolic blood pressure and pulse rate for the two studied drugs, which were less affected in the ephedrine group as compared with the phenylephrine group. Neonatal Apgar scores were within normal range in both groups. With respect to arterial and venous blood gases, there was significant difference in base excess and nonsignificant difference in pH and PO 2 between the two groups. Conclusion Both vasopressors phenylephrine (75 μg) and ephedrine (6 mg) were given as a bolus dose to pre-eclamptic candidates receiving spinal anesthesia, causing hemodynamic stability to mothers. However, the usage of phenylephrine was safer for fetal outcome than epinephrine in high-risk cesarean sections (pre-eclampsia) under spinal anesthesia.