Abstract

Oral anticoagulants [OACs; Vitamin K antagonists (VKAs) and direct-acting anticoagulants (DOACs)] are effective for preventing stroke in patients with atrial fibrillation (AF). Switching between OACs occurs because of the unique safety, effectiveness, and convenience attributes of each OAC, and patient factors. Studies on factors associated with OAC switching have been limited to switches from VKA to DOAC and data on other OAC class switches are sparse. The objective of this study was to determine factors associated with OAC switching for VKA to DOAC, DOAC to VKA, and DOAC to DOAC switches.

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