Abstract
Background: Although endothelial cell protein C receptor (EPCR) gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached.Objective and methods: A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidate the potential relationship between the EPCR gene Ser219Gly polymorphism and VTE. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed or random effect models.Results: The current meta-analysis suggested that there was a significant association between EPCR gene Ser219Gly polymorphism and VTE under allelic (OR: 1.42, 95% CI: 1.21–1.66, P = 1.30 × 10−5), recessive (OR: 2.02, 95% CI: 1.44–2.85, P = 5.35 × 10−5), homozygous (OR: 2.24, 95% CI: 1.59–3.16, P = 3.66 × 10−6), and additive genetic models (OR: 1.63, 95% CI: 1.30–2.04, P = 2.24 × 10−5).Conclusions: EPCR gene Ser219Gly polymorphism was associated with an elevated risk of VTE and the Gly residue carriers of the EPCR gene might be predisposed to VTE.
Highlights
Venous thromboembolism (VTE) encompasses deep vein thrombosis (DVT) and pulmonary empolism (PE)
The current meta-analysis suggested that there was a significant association between endothelial protein C receptor (EPCR) gene Ser219Gly polymorphism and VTE under allelic (OR: 1.42, 95% confidence intervals (CIs): 1.21–1.66, P = 1.30 × 10−5), recessive (OR: 2.02, 95% CI: 1.44–2.85, P = 5.35 × 10−5), homozygous (OR: 2.24, 95% CI: 1.59–3.16, P = 3.66 × 10−6), and additive genetic models (OR: 1.63, 95% CI: 1.30–2.04, P = 2.24 × 10−5)
EPCR gene Ser219Gly polymorphism was associated with an elevated risk of VTE and the Gly residue carriers of the EPCR gene might be predisposed to VTE
Summary
Venous thromboembolism (VTE) encompasses deep vein thrombosis (DVT) and pulmonary empolism (PE). DVT indicates the formation of a venous thrombus typically in the deep veins of the legs, which may undergo embolization when the clot is dislodged from the underlying endothelium and carried downstream by circulatory system potentially reaching the lungs where it can cause a sudden occlusion of pulmonary circulation, referred to as PE. This event presents as a clinical emergency that can endanger the patient’s life. Endothelial cell protein C receptor (EPCR) gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached
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