Abstract
Introduction and Objective: In the practice of traditional ayurvedic medicine in Sri Lanka, a number of herbs have been recognized for their potential benefits in the treatment of liver disorders. This study was conducted to investigate the protective effect of Epaltes divaricata plant extract in paracetamol induced hepatotoxicity in mice. Methods: ICR mice (n=20) were treated with acetaminophen at a single dose of 300 mg/kg (after a 16h fast) to induce hepatotoxicity. Drug control group and pre and post-treated groups were administered 0.9 g/kg of Asparagus falcatus orally. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatise (ALP) and liver reduced glutathione (GSH) levels were determined. Liver damage was also assessed histopathologically. The effect of the plant extract was compared with N-acetyl cysteine. Results:Acetaminophen produced liver damage, as manifested by a significant rise (P Discussion: This study shows the ability of the aqueous extract of Epaltes divaricata to preserve liver functions in mice treated with high dose of paracetamol. Galle Medical Journal 2015 20(1): 1-7
Highlights
Introduction and ObjectiveIn the practice of traditional ayurvedic medicine in Sri Lanka, a number of herbs have been recognized for their potential benefits in the treatment of liver disorders
A small proportion is metabolized through cytochromes P450 2E1, 1A2, 3A4, and 2A6 to form a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI) which binds covalently to proteins
The hepatoprotective effect of the plant extract was identified by the determination of serum enzyme activities of ALT, AST, alkaline phosphatise (ALP), and histopathology
Summary
Introduction and ObjectiveIn the practice of traditional ayurvedic medicine in Sri Lanka, a number of herbs have been recognized for their potential benefits in the treatment of liver disorders. This study was conducted to investigate the protective effect of Epaltes divaricata plant extract in paracetamol induced hepatotoxicity in mice. Results: Acetaminophen produced liver damage, as manifested by a significant rise (P
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
