Abstract
The purpose of our study was to compare the efficacy and safety of vaginal misoprostol versus surgical evacuation in the management of first trimester aborted pregnancies. One G1 group received a drug procedure: misoprostol 800 ug vaginally repeated as needed 24 hours later. One G2 group underwent surgical evacuation. The main epidemiological characteristics of the patients were comparable between the two groups. Analysis of misoprostol efficacy by parity, gestational age, and serum BHCG level did not show significant differences. The success rate was comparable in G2. Immediate and short-term complications were less frequent with medical treatment with a cumulative rate of 8% versus 24% with surgical treatment. All these undesirable effects were well tolerated and transient and did not affect the acceptability of the medical treatment (88% of G1 patients were satisfied compared to 58% of G2). Vaginal misoprostol is a promising alternative to surgical evacuation of terminated first trimester pregnancies.
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