Abstract
The RAS/MAPK pathway is involved in the cell cycle, cell growth, differentiation, and senescence. Germline variants that result in RAS/MAPK pathway dysregulation are associated with congenital diseases with overlapping clinical features, known as RASopathies. Mosaic variants in RAS genes, HRAS, KRAS, and NRAS, have been recently described in disorders of somatic mosaicism (DoSM), including vascular tumors, vascular malformations, nevus sebaceus, keratinocytic epidermal nevi, congenital nevi, segmental overgrowth, and digital anomalies.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
