Abstract
Hereditary cancer caused by inherited pathogenic variants clusters in families and is typically associated with young age at diagnosis, multiple primary tumors, and both high and early mortality. For patients with an existing cancer diagnosis, detection of pathogenic germline variants (PGV) by genetic testing not only provides prognostic information, but also assists in selection of appropriate therapeutic management. Previous studies have demonstrated that knowledge of PGV status before breast surgery has a significant impact on the type of surgical procedure patients choose.
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