Abstract
Declarative memory, including episodic and semantic memories, enables us to connect the present things with the past experiences. E1A binding protein p300 (EP300) and cAMP response element binding-binding protein (CREBBP), two important histone acetyltransferases (HATs) of KAT3 family, are involved in the development of cognitive aging such as the decreasing in episodic memory. However, no evidence suggested their potential roles in individual difference in declarative memories of youth. In the present study, we investigated whether EP300 and CREBBP genes modulated individual difference in declarative memory among youth subjects by using Remember (R)/Know (K) paradigm. The results showed that rs4822004 in EP300 modulated R responses (episodic memory) as controlling K responses (β = 0.076, R2 = 0.385, F = 180.322, p = 0.020). Moreover, we also found that rs130032 in CREBBP also modulated the performance of R responses after controlling K responses (β = 0.068, R2 = 0.384, F = 178.483, p = 0.038). The study suggests that EP300 and CREBBP genes contribute to the individuals’ difference in episodic memory, which provides evidence on the roles of histone acetylation activity in human declarative memory.
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